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Halogens are ortho–para directors. They are more electronegative than carbon. Therefore, as ring substituents, they can withdraw electrons through the inductive effect and deactivate the aromatic ring towards electrophilic substitution. Halogens also have an electron-donating resonance effect on the ring, which influences the orientation of the incoming electrophile. If an electrophile attacks at the ortho or the para position, the halogen donates electrons and stabilizes the intermediate...
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In Reply: for Dr. Lockhart

William M Callaghan1, William A Grobman, Sarah J Kilpatrick

  • 1Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California California Maternal Quality Care Collaborative, Palo Alto, California Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New york.

Obstetrics and Gynecology
|August 28, 2014
PubMed
Summary

No abstract available in PubMed .

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