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Updated: Apr 25, 2026
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Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
Published on: June 29, 2013
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[Second trimester growth restriction and underlying fetal anomalies]
S Vanlieferinghen1, J-P Bernard1, L J Salomon1
1Service d'obstétrique et de médecine materno-fœtale, université Paris Descartes, hôpital Necker-Enfants-Malades, Assistance publique-Hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France.
Gynecologie, Obstetrique & Fertilite
|August 29, 2014
Summary
Second trimester fetal growth restriction (FGR) affects 2.8% of fetuses. Abnormal karyotypes or malformations are present in 15% of FGR cases, influencing prenatal management.
Area of Science:
- Perinatology
- Prenatal Diagnosis
- Fetal Medicine
Background:
- Second-trimester fetal growth restriction (FGR) is a significant concern in prenatal care.
- Identifying associated chromosomal abnormalities and fetal defects is crucial for accurate diagnosis and management.
Purpose of the Study:
- To determine the incidence of chromosomal abnormalities, syndromic associations, and fetal defects in second-trimester FGR.
- To analyze factors influencing prenatal management and counseling for FGR.
Main Methods:
- Retrospective review of 239 fetuses with FGR (abdominal circumference <5th percentile) between 14-27 weeks gestation.
- Exclusion of multiple pregnancies.
- Analysis of medical records for malformations, aneuploidy, and pregnancy outcomes.
Main Results:
- FGR was identified in 2.8% of 8626 fetuses.
- 15% of FGR cases had abnormal karyotypes or syndromic associations, with Trisomy 18 being the most common (4.2%).
- 28% had morphological abnormalities without aneuploidy; common defects included short femur, omphalocele, and gastroschisis.
Conclusions:
- The study highlights the spectrum of abnormalities associated with second-trimester FGR.
- Absence of malformations, degree of growth restriction, maternal age, and amniotic fluid index are key factors for prenatal counseling.
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