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Anticancer and Antibacterial Activity of Hyperforin and Its Derivatives
Brigida Immacolata Pia Schiavone1, Luisella Verotta, Antonio Rosato
1Department of Pharmacy, University of Bari "Aldo Moro", 70124 Bari, Italy.
Abstract:
Hyperforin is a natural phloroglucinol that has been know for the treatment of depression. Hyperforin displays also antibacterial, antiproliferant and antiangiogenic activity. Synthetic derivatives of hyperforin have also recently been reported to possess increased bioactivity. The clinical applications are limited by the hydrophobic characteristics and the instability of the molecule. In this review we discuss about some of the derivatives of hyperforin (aristoforin, tetrahydrohyperforin and octahydrohyperforin) that demonstrated promising antitumor activity. Among these, octahydrohyperforin also possesses antibacterial activity against both the planktonic and biofilm states of bacteria.
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