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Canagliflozin-Associated Acute Pancreatitis
1Department of Hospital Medicine (UHS), United Hospital, Allina Health, St. Paul, MN.
American Journal of Therapeutics
|September 5, 2014
Summary
Canagliflozin, a new type 2 diabetes drug, may cause acute pancreatitis. This is the first reported case linking this medication to the serious condition.
Area of Science:
- Endocrinology
- Pharmacology
- Gastroenterology
Background:
- Type 2 diabetes mellitus is a metabolic disorder managed with various pharmacological agents.
- Sodium-glucose cotransporter 2 (SGLT2) inhibitors represent a novel class of antidiabetic drugs.
- Canagliflozin is an SGLT2 inhibitor approved for glycemic control in type 2 diabetes.
Observation:
- A patient initiated on canagliflozin treatment for type 2 diabetes mellitus experienced an adverse event.
- The patient presented with symptoms indicative of moderately severe acute pancreatitis.
- The onset of pancreatitis occurred subsequent to the initiation of canagliflozin therapy.
Findings:
- This case report details the first documented instance of acute pancreatitis associated with canagliflozin use.
- The clinical presentation suggests a potential causal link between canagliflozin and the development of acute pancreatitis.
- Exclusion of other common causes of pancreatitis was considered in the patient's evaluation.
Implications:
- This finding highlights a potential, previously unrecognized adverse effect of canagliflozin.
- Clinicians should be vigilant for symptoms of acute pancreatitis in patients treated with canagliflozin.
- Further investigation into the mechanism and incidence of canagliflozin-associated pancreatitis is warranted.
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