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Updated: Apr 24, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
[From treating to curing--new era in the approach to patients with atrial fibrillation]
Insights
Atrial fibrillation ablation is an effective treatment for the most common heart arrhythmia. New technologies and improved understanding are enhancing success rates and safety, expanding treatment options.
Area of Science:
- Cardiology
- Electrophysiology
Context:
- Atrial fibrillation (AF) is the most prevalent arrhythmia, with increasing incidence and prevalence.
- AF significantly increases morbidity and mortality.
- Current antiarrhythmic drugs have limited efficacy and severe adverse effects.
Purpose:
- To review the current state and recent advancements in atrial fibrillation ablation.
- To highlight the evolving role of ablation technologies and their impact on treatment outcomes.
- To discuss the implications of new data and guidelines for AF management.
Summary:
- Pulmonary vein antrum ablation is an established, efficient treatment for AF with success rates of 60-93% and low complication rates.
- Recent technological innovations, including novel ablation catheters, have improved procedure efficiency, safety, and reduced the need for general anesthesia.
- Updated European Society of Cardiology guidelines now recommend AF ablation as a first-line or second-line therapy, reflecting its growing acceptance and efficacy.
Impact:
- Atrial fibrillation ablation is becoming a cornerstone therapy for AF, offering improved patient outcomes and quality of life.
- Advancements in ablation technology are expanding the eligible patient population and potentially reducing healthcare costs.
- The evolving landscape of AF treatment signifies a paradigm shift towards more effective and safer interventional strategies.
Abstract:
Atrial fibrillation is the most common arrhythmia and its incidence and prevalence are growing steadily. It causes increased morbidity and mortality, while keeping patients in sinus rhythm was proven to decrease mortality rate. Nevertheless, antiarrhythmic drugs are limited in efficacy and have life-threatening adverse effects, thus neutralizing their benefits. Over the last years, ablation of pulmonary vein antrum has proven to be efficient in treating patients with atrial fibrillation. It has a success rate of 60-93% and overall complication rate of 6%. Recently, new ablation technologies entered the market and there has been improved understanding of the pathogenesis of atrial fibrillation. These improvements have led to better results and lower complication rates for atrial fibrillation ablation as a treatment option. In addition, new data was published regarding ablation treatment in the relatively healthy" elderly population. In the recent European Society of Cardiology (ESC) guidelines, ablation treatment for atrial fibrillation was graded as Class IA for patients who failed one antiarrhythmic drug and as Class IIA for patients who preferred ablation as their first treatment option. The field of atrial fibrillation ablation is evolving rapidly. The novel ablation catheters (the circular ones: PVAC and nMARQ, and the CryoCath balloon catheter) provide better tools for treating atrial fibrillation by reducing procedure time, making it possible to avoid general anesthesia and they are safer for use even in low-volume centers. These developments may enlarge the population that could be treated with ablation. It seems that we are in the middle of a process of change in the concept of treating atrial fibrillation.
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