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Gene panel testing for inherited cancer risk.

Michael J Hall¹, Andrea D Forman¹, Robert Pilarski¹

¹From Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania; Department of Internal Medicine, Division of Human Genetics, Ohio State University Comprehensive Cancer Center, Columbus, Ohio; Clinical and Translational Hereditary Cancer Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee; and Division of Population Science, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania.

Journal of the National Comprehensive Cancer Network : JNCCN

|September 6, 2014

Summary

Gene panel testing uses next-generation sequencing to assess inherited cancer risk by analyzing multiple genes simultaneously. Genetic counseling is crucial for understanding panel testing

Area of Science:

Genetics
Oncology
Molecular Biology

Background:

Next-generation sequencing (NGS) enables parallel assessment of multiple genes for inherited cancer risk.
Gene panel testing is a viable option for genetic counseling and cancer risk assessment.

Purpose of the Study:

To describe available gene panel testing options for inherited cancer susceptibility.
To discuss the advantages and challenges of various gene panels.
To outline clinical scenarios, testing, and counseling considerations for gene panel use.

Main Methods:

Review of clinically available gene panel testing options.
Analysis of potential benefits and drawbacks of different panel types.
Examination of clinical utility and counseling implications.

Main Results:

Multiple gene panel testing options exist for assessing inherited cancer risk.
Panels offer advantages but also present challenges in interpretation and application.
Specific clinical scenarios benefit from comprehensive gene panel analysis.

Conclusions:

Gene panel testing is a valuable tool for evaluating inherited cancer susceptibility.
Consultation with a cancer genetic specialist is recommended for optimal patient and family care.
Informed decision-making and genetic counseling are essential components of the testing process.

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