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Updated: Apr 24, 2026

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
Published on: November 22, 2014
Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein
Muhammad Jbara1, Mallikanti Seenaiah, Ashraf Brik
1Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel. abrik@bgu.ac.il.
Abstract:
Presented here is a solid phase chemical ligation strategy employing native chemical ligation and the commercially available Rink-amide linker as a key element in our approach. The method was applied for the synthesis of histone H2B, which sets the ground for the rapid preparation of posttranslationally modified analogues of this protein.
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