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Wheezing is common in children with sickle cell disease when compared with controls
Najibah A Galadanci1, Wayne H Liang2, Aisha A Galadanci1
1Department of Haematology and Blood Transfusion, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
Journal of Pediatric Hematology/Oncology
|September 9, 2014
Summary
Children with sickle cell disease (SCD) have a significantly higher rate of wheezing compared to children without SCD. This increased prevalence of wheezing occurs both with and without common colds.
Area of Science:
- Pediatric Pulmonology
- Hematology
- Epidemiology
Background:
- Wheezing in children with sickle cell disease (SCD) can occur independently of asthma.
- The prevalence of wheezing in children with SCD versus controls is not well-established.
Purpose of the Study:
- To test the hypothesis that children with SCD experience a higher rate of wheezing than children without SCD.
- To compare the prevalence of wheezing in pediatric SCD patients and a control group.
Main Methods:
- A case-control study was conducted with 163 children with SCD (cases) and 96 controls.
- Respiratory symptoms, including wheezing, were assessed using parent reports from the American Thoracic Society questionnaire.
- Data were collected from a community hospital in Nigeria.
Main Results:
- Children with SCD were significantly more likely to report wheezing, both with (17.3% vs. 2.1%) and without (4.9% vs. 0%) colds.
- SCD status was the only variable significantly associated with wheezing in multivariable analysis (OR=18.7).
- Children with SCD had 9.8 times greater odds of experiencing wheezing.
Conclusions:
- Children with sickle cell disease exhibit a substantially higher incidence of wheezing compared to their peers without the condition.
- SCD is a significant risk factor for wheezing in children, irrespective of asthma status or presence of a cold.
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