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Paediatric rheumatic disease: Diagnosing macrophage activation syndrome in systemic JIA
Sebastiaan J Vastert1, Berent J Prakken1
1Center for Molecular and Cellular Intervention, Department of Pediatric Rheumatology and Immunology, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, Netherlands.
Abstract:
Macrophage activation syndrome (MAS) in systemic juvenile idiopathic arthritis (sJIA) is difficult to distinguish from active sJIA or sepsis. A collaborative effort scoring the performance of different clinical diagnostic criteria provides valuable guidance to clinicians, but challenges in the diagnosis of sJIA-related MAS remain.
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