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Updated: Apr 24, 2026

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Mifepristone modulates serotonin transporter function.

Chaokun Li1, Linlin Shan1, Xinjuan Li1

  • 1Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China.

Neural Regeneration Research
|September 11, 2014
PubMed
Summary
This summary is machine-generated.

Mifepristone, a treatment for psychotic depression, directly inhibits serotonin transporter activity. This finding reveals a new mechanism for how this drug works by targeting serotonin transporters.

Keywords:
NSFC grantXenopus oocyteantidepressantscurrent recordingdepressionmifepristonenerve regenerationneural regenerationpsychotic depressionserotoninserotonin transmissionserotonin transportertwo-electrode voltage clamp

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • Psychotic depression treatment often involves regulating serotonin.
  • Mifepristone is a potential therapeutic agent for psychotic depression.
  • The precise mechanism of mifepristone's effect on serotonin transporter expression remains unclear.

Purpose of the Study:

  • To investigate the mechanism by which mifepristone affects serotonin transporter activity.
  • To determine if the serotonin transporter is a direct pharmacological target of mifepristone.

Main Methods:

  • Cloning of the human brain serotonin transporter into Xenopus oocytes for an in vitro expression system.
  • Utilizing two-electrode voltage clamp recordings to measure serotonin transporter activity.

Main Results:

  • Mifepristone was found to attenuate serotonin transporter activity.
  • Evidence suggests mifepristone directly inhibits the serotonin transporter.

Conclusions:

  • The serotonin transporter is a pharmacological target of mifepristone.
  • This study elucidates a novel mechanism for mifepristone in treating psychotic depression through direct serotonin transporter inhibition.