Related Experiment Video

Updated: Apr 24, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

7.0K

Clinical characteristics and prognostic factors in childhood bacterial meningitis: a multicenter study

Ozden Türel1, Canan Yıldırım2, Yüksel Yılmaz2

  • 1Department of Pediatrics, Section of Pediatric Infectious Diseases, Faculty of Medicine, Marmara University, İstanbul, Turkey.

Balkan Medical Journal
|September 11, 2014
PubMed

Insights

Clinical features and sequelae of acute bacterial meningitis (ABM) in children were evaluated. Speech and language problems were the most common sequelae, particularly in younger children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neurology

Background:

  • Acute bacterial meningitis (ABM) is a serious infection in children.
  • Understanding its clinical features and long-term consequences is crucial for effective management.

Purpose of the Study:

  • To evaluate the clinical characteristics of children diagnosed with ABM.
  • To identify and assess the sequelae resulting from ABM in pediatric patients.

Main Methods:

  • A multicenter retrospective study involving chart review of children hospitalized with ABM.
  • Follow-up assessments included neurological examinations, hearing evaluations, and neurodevelopmental tests.

Main Results:

  • 283 children were included; median age was 12 months, with 68.6% males.
  • Fever was nearly universal; younger children (<6 months) presented with feeding difficulties, older children (>24 months) with vomiting and meningeal signs.
  • 26% experienced major sequelae, most commonly speech/language problems (14.5%); 6 patients had severe disabilities.
  • Focal neurologic signs, turbid CSF, and younger age (<24 months) were associated with increased sequelae.

Conclusions:

  • Clinical presentation of ABM in children is age-dependent.
  • Speech and language impairments are the most frequent long-term sequelae of pediatric ABM.
Abstract

Keywords:
Bacterial meningitischildrensequelaesigns and symptoms

More Related Videos

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat08:27

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Published on: October 29, 2014

13.1K
A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)07:01

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

917

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
8
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
4
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
179
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
8
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
77
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
8