Related Experiment Video
Updated: Apr 24, 2026

08:19
Generating Transposon Insertion Libraries in Gram-Negative Bacteria for High-Throughput Sequencing
Published on: July 7, 2020
9.8K
Overview on the current antibiotic containing agents used in endodontics
1Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Sehora, Jammu and Kashmir, India.
North American Journal of Medical Sciences
|September 12, 2014
Summary
Local antibiotics are more effective than systemic ones for targeting root canal bacteria. This review examines antibiotic dental agents as key adjuncts in endodontic therapy.
Area of Science:
- Endodontic Microbiology
- Dental Pharmacology
Background:
- Antibiotics are widely used in endodontics, both systemically and locally.
- Local antibiotic application offers superior efficacy by targeting bacteria within the complex root canal system.
Purpose of the Study:
- To review various antibiotic-containing dental agents used in endodontics.
- To synthesize current literature on local antibiotic applications in root canal treatment.
Main Methods:
- A web-based literature search was conducted on MedLine.
- Included review articles published in dental journals within the last 10 years.
- Relevant articles and cross-references were reviewed and synthesized.
Main Results:
- Local antibiotic delivery is highlighted as more effective than systemic administration.
- Antibiotic agents are crucial adjuncts to conventional root canal treatment protocols.
- The review synthesizes data on diverse antibiotic dental agents.
Conclusions:
- Local antibiotics provide targeted bacterial eradication in endodontics.
- Antibiotic-containing agents are valuable additions to endodontic treatment strategies.
- Further research synthesis supports the role of local antibiotics in root canal therapy.
More Related Videos
Related Concept Videos
Mechanism of Antibiotic Resistance in MRSA
198
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
198
Development of Antibiotic Resistance
2.0K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
2.0K
Antimicrobial Effectiveness
2.3K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
2.3K
Clinical Significance of Antibiotic Resistance
80
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
80
Antibiotic Selection
48.8K
Overview
48.8K
The Oral Microbiota
81
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
81

