Antimullerian hormone in cases of different reproductive pathologies

The aim of this study was to define the importance of determination of AMH during different reproductive pathologies and to identify the correlations between the tests currently used in ovarian reserve assessment (AMH, FSH, AFC) in different age groups of infertile woman. Study population consisted of 153 women. In 41 women with different reproductive pathologies we evaluate the values of AMH. 112 women with infertility were divided into the three age groups: group I <35 years (n=39); group II 35-40 years (n=31); and group III >40 years (n=42). AMH, FSH and AFC were determined on days 2-3 of menstrual cycle. We evaluated the AMH values during different reproductive pathologies (n=41) and found that: in cases of gonadal dysgenesis and ootesticular disorders AMH levels are decreased. In cases of POI AMH levels were extremilly low. Normal levels of AMH were detected in cases of Hyperprolactinemia and Hypogonadotropic hypogonadism. In patients with PCOS AMH levels were increased. The correlation analysis between ovarian reserve tests was performed in 112 infertile women. Generally, age is in a significant high negative correlation with AMH level (rs=-0.67, p<0.0001) and AFC (rs=-0.55, p<0.0001), and in positive correlation with FSH (rs=0.38, p<0.0001). AMH negatively correlates with FSH (rs=-0.48, p<0.0001) and positively with AFC (r=0.71, p=0.0001). There is a moderate negative relation between FSH and AFC (r=-0.41, p=0.0001) and moderate positive relation between age and FSH (rs=0.38, p<0.0001). The correlation analysis performed in separate groups showed that AMH and AFC in all three study groups correlates positively and are statistically significant (r=0.57, p<0.0001; r=0.69, p<0.0001; r=0.47, p<0.002 respectively). Whereas statistically significant correlation between FSH and AMH detected only in the first and second age groups (r=-0.41, p<0.02; r=-0.55, p<0.0001 respectively). Statistically significant correlation between FSH and AFC revealed only in the third age group (r=-0.42, p<0.006), as well as between age and AFC only in first age group (r=-0.35, p<0.03). Nowadays, among used ovarian reserve assesment tests AMH should be considered to be more reliable, than FSH. Serum AMH level is in strongly positive correlation with AFC. Using of AMH measurement in combination with AFC may improve the evaluation of ovarian reserve. Determination of AMH also may be of diagnostic value in cases of different reproductive pathologies.