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Alterations of redox-status during psoriasis
M Matoshvili1, A Katsitadze1, T Sanikidze1
1Tbilisi State Medical University, Department of Dermatology and Venereology, Department of Medical Physics and Biophysics, Department of Human Normal Anatomy, Georgia; University of Rome "Sapienza", Department of Dermatology and Venereology, Italy.
Psoriasis patients exhibit an altered blood redox balance, with increased oxidative stress markers and decreased antioxidant activity correlating with disease severity. This suggests free radical oxidation plays a significant role in psoriasis.
Area of Science:
- Dermatology
- Oxidative Stress Research
- Biochemistry
Background:
- The skin is continuously exposed to oxidative stress from reactive oxygen species (ROS).
- Psoriasis is a chronic inflammatory skin condition potentially linked to oxidative damage.
Purpose of the Study:
- To investigate the role of free radical oxidation in psoriasis patients.
- To assess the correlation between redox balance and psoriasis severity.
Main Methods:
- Electron Paramagnetic Resonance (EPR) and spectrophotometry were used to analyze blood samples.
- Measured parameters included superoxide, lipoperoxide free radicals, Mn2+-ions, ceruloplasmin, Fe3+-transferrin, catalase (CAT), and superoxide dismutase (SOD).
- Patients were graded using the Psoriasis Area Severity Index (PASI).
Main Results:
- Psoriasis patients showed increased oxidized ceruloplasmin and decreased Fe3+-transferrin compared to controls.
- Catalase activity increased, while superoxide dismutase activity decreased with increasing psoriasis severity.
- Lipoperoxide free radicals and Mn2+-containing complexes were detected, indicating oxidative stress.
Conclusions:
- Psoriasis is associated with an altered blood redox balance.
- The degree of redox balance impairment correlates with the severity of psoriasis.
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