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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

815
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

913
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Related Experiment Video

Updated: Apr 24, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
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Bioengineering kidneys for transplantation.

Maria Lucia L Madariaga1, Harald C Ott1

  • 1Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Harvard Stem Cell Institute, Boston, MA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA.

Seminars in Nephrology
|September 14, 2014
PubMed
Summary
This summary is machine-generated.

Bioengineered kidney grafts offer a promising solution for chronic kidney disease patients facing organ shortages and transplantation challenges. This regenerative medicine approach aims to overcome limitations of current treatments like dialysis and traditional transplants.

Keywords:
Kidneybioengineeringorgan engineeringperfusion decellularizationtransplantation

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Area of Science:

  • Regenerative Medicine
  • Biomedical Engineering
  • Nephrology

Background:

  • Chronic kidney disease affects 1 in 10 Americans, with kidney failure leading to nearly 90,000 deaths annually.
  • End-stage renal disease patients typically face hemodialysis or transplantation, both with significant limitations.
  • Organ shortages and the need for immunosuppression restrict kidney transplantation viability.

Purpose of the Study:

  • To review the history and current status of bioengineered kidney grafts.
  • To discuss future considerations and challenges for clinical translation of bioengineered kidneys.
  • To highlight the potential of bioengineered grafts in regenerative medicine for critical clinical needs.

Main Methods:

  • Review of historical developments in organ bioengineering.
  • Analysis of current research in stem cell and developmental biology applied to kidney tissue engineering.
  • Discussion of challenges in translating bioengineered kidneys to clinical practice.

Main Results:

  • Bioengineered kidney grafts present a theoretical solution to donor organ shortages and immunosuppression requirements.
  • The integration of tissue engineering, stem cell, and developmental biology principles is key.
  • Significant challenges remain for the clinical translation of these advanced grafts.

Conclusions:

  • Bioengineered kidney grafts hold significant promise for advancing regenerative medicine.
  • This approach could potentially meet the critical clinical need for viable kidney replacement therapies.
  • Further research and development are essential to overcome hurdles to clinical application.