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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Angiosarcoma arising from the frontal sinus.

Senja Tomovic1, Evelyne Kalyoussef1, Neena M Mirani2

  • 1Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.

American Journal of Otolaryngology
|September 14, 2014
PubMed
Summary
This summary is machine-generated.

Primary sinonasal angiosarcomas are rare, aggressive tumors. This report details a unique frontal sinus angiosarcoma case in a young woman, highlighting treatment challenges and future therapeutic options.

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Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Pathology

Background:

  • Primary sinonasal angiosarcomas are exceptionally rare and aggressive vascular tumors.
  • Typically affecting middle-aged individuals, they usually originate in the nasal cavity.
  • Surgical excision is the primary treatment modality when feasible.

Observation:

  • A unique case of angiosarcoma arising from the frontal sinus in a young woman is presented.
  • This represents the first reported instance of frontal sinus angiosarcoma in English literature.
  • The patient presented with distant metastasis, indicating advanced disease.

Findings:

  • The case highlights the aggressive nature of sinonasal angiosarcomas, even in younger patients.
  • Distant metastasis at presentation underscores the poor prognosis associated with advanced stages.
  • Traditional treatment options for advanced disease and poor prognosis are discussed.

Implications:

  • This case expands the known anatomical origins of sinonasal angiosarcomas.
  • It emphasizes the need for exploring alternative and novel treatment strategies.
  • Emerging chemotherapeutic regimens offer potential for improved disease control in advanced cases.