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Updated: Apr 24, 2026

Gene Transfer for Ischemic Heart Failure in a Preclinical Model
Published on: May 15, 2011
Potential applications of pharmacogenomics to heart failure therapies
Kishan S Parikh1, Tariq Ahmad2, Mona Fiuzat2
1Division of Cardiology, Duke University Medical Center, 3428, Durham, NC 27710, USA.
Abstract:
Pharmacogenomics explores one drug's varying effects on different patient genotypes. A better understanding of genomic variation's contribution to drug response can impact 4 arenas in heart failure (HF): (1) identification of patients most likely to receive benefit from therapy, (2) risk stratify patients for risk of adverse events, (3) optimize dosing of drugs, and (4) steer future clinical trial design and drug development. In this review, the authors explore the potential applications of pharmacogenomics in patients with HF in the context of these categories.
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