[Endothelial cell damaging mechanism in aging organism]

Aging includes various changes, from the dysfunction of different organs to cellular damages. Recent years, there is a growing attention on the relationship between aging and endothelial cell damage. Aging bodies' endothelial cells are damaged through many ways, all contribute to structural and functional changes. And these pathways are being researched more and more deeply. This paper reviews the change of aging organism and the effects on endothelial cells, focuses on the different pathways on endothelial damage, and also discusses the relevant regulatory factors, which can be treated as new direction for inhibiting endothelial damages and provide relevant strategies for delaying damages.