Related Experiment Video
Updated: Apr 23, 2026

07:23
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
1.2K
[LncRNAs and cardiovascular diseases].
Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|September 16, 2014
Summary
Long noncoding RNAs (lncRNAs) are increasingly linked to cardiovascular disease. This review explores lncRNA functions and their connection to heart disease, aiding understanding of its causes and mechanisms.
Area of Science:
- Genetics
- Medical Informatics
- Cardiovascular Medicine
Background:
- Cardiovascular disease poses a significant global health threat.
- Noncoding RNAs, particularly long noncoding RNAs (lncRNAs), are emerging as critical players in biological processes.
- lncRNAs were once considered non-functional but are now recognized for their regulatory roles.
Purpose of the Study:
- To review the known functions and characteristics of lncRNAs.
- To explore the relationship between lncRNAs and cardiovascular disease.
- To enhance the understanding of cardiovascular disease etiology and pathophysiology.
Main Methods:
- Literature review of existing studies on lncRNAs and cardiovascular disease.
- Analysis of genetic and medical informatics data related to lncRNAs.
- Synthesis of current evidence on lncRNA mechanisms in cardiovascular contexts.
Main Results:
- lncRNAs exhibit diverse functions, including gene regulation and modulation of cellular processes.
- Growing evidence links specific lncRNAs to various cardiovascular conditions.
- The precise molecular mechanisms of lncRNAs in cardiovascular disease are still under investigation.
Conclusions:
- lncRNAs represent a promising area of research for understanding cardiovascular disease.
- Further investigation into lncRNA functions could reveal novel therapeutic targets.
- lncRNA research is crucial for advancing basic cardiovascular medicine.
Related Concept Videos
lncRNA - Long Non-coding RNAs
7.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
7.5K
lncRNA - Long Non-coding RNAs
2.6K
2.6K
Regulation of the Cardiovascular System
5.3K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
5.3K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
750
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
750
Coronary Artery Disease I: Introduction
1.8K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Coronary Artery Disease II: Pathophysiology
1.0K
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.0K
