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Cells Coordinate Growth and Proliferation

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...

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Morphogenesis

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Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.

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Related Experiment Video

Updated: Apr 23, 2026

An Analytical Tool that Quantifies Cellular Morphology Changes from Three-dimensional Fluorescence Images

An Analytical Tool that Quantifies Cellular Morphology Changes from Three-dimensional Fluorescence Images

Published on: August 31, 2012

How cells explore shape space: a quantitative statistical perspective of cellular morphogenesis.

Zheng Yin¹, Heba Sailem, Julia Sero

¹Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology

|September 16, 2014

Summary

This summary is machine-generated.

Cells explore limited stable shapes, or attractor states, influenced by internal biophysics and external signals. Environmental changes dynamically alter these cell shape landscapes, potentially explaining complex tissue formation.

Keywords:

RNAi cellular morphogenesis high content screening morphological complexity morphological landscapes signaling networks

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Area of Science:

Cell biology
Biophysics
Systems biology

Background:

Cell morphology is crucial for function but its dynamic regulation is complex.
Understanding the principles governing cell shape diversity is a key challenge in biology.

Purpose of the Study:

To identify the fundamental principles governing cell shape regulation.
To explore how cell-intrinsic and cell-extrinsic factors shape cellular morphology.
To hypothesize mechanisms for generating complex tissue morphologies from simple cell shapes.

Main Methods:

Statistical analysis of single-cell shape datasets.
Systematic gene depletion experiments to probe morphological landscapes.
Analysis of cell-extrinsic factors (informational and mechanical stimuli).

Main Results:

Cellular morphology is organized into a limited number of stable 'attractor states'.
Cell-intrinsic factors (e.g., cytoskeleton) define landscape topology.
Cell-extrinsic factors (signals, mechanical forces) control landscape exploration and topology.
Dynamic adaptation of morphological landscapes to environmental fluctuations.

Conclusions:

Cellular morphology is governed by a limited set of stable states within a defined landscape.
Both internal cellular properties and external environmental cues are critical for shaping cell morphology.
Dynamic adaptation of these landscapes may explain the generation of complex multicellular structures.