Related Experiment Video
Updated: Apr 23, 2026
09:44
Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
804
Spray-on transdermal drug delivery systems.
1Fairleigh Dickinson University, School of Pharmacy, Division of Pharmaceutical Sciences , 230 Park Avenue Florham Park, NJ 07932 , USA +1 973 443 8435 ; +1 973 443 8412 ; ibrahisa@mail.uc.edu.
Expert Opinion on Drug Delivery
|September 18, 2014
Summary
Spray-on transdermal systems (TSS) offer an effective method for drug delivery, overcoming skin
Area of Science:
- Pharmaceutical Sciences
- Dermatology
- Drug Delivery Systems
Background:
- Transdermal drug delivery bypasses first-pass metabolism but faces challenges due to skin's barrier properties.
- Novel technologies are crucial for enhancing skin permeability for effective transdermal administration.
- Spray-on transdermal systems (TSS) represent an innovative approach to overcome these limitations.
Purpose of the Study:
- To evaluate the principles and advantages of transdermal spray-on systems (TSS) for drug delivery.
- To highlight the mechanisms by which TSS facilitate drug permeation through the skin.
- To compare TSS with traditional transdermal delivery methods.
Main Methods:
- TSS formulation typically includes drug, volatile solvent, and penetration enhancers.
- Drug delivery is facilitated by solvent evaporation and drug-solvent drag into the skin.
- Solvent evaporation increases drug thermodynamic activity, enhancing skin loading.
Main Results:
- TSS are easily applied, allowing for flexible and precise drug dosage.
- These systems exhibit a lower incidence of skin irritation compared to other methods.
- Uniform drug distribution is achieved with minimal vehicle deposition on the skin surface.
Conclusions:
- Transdermal spray-on systems offer a user-friendly and effective alternative to conventional transdermal patches.
- Their ease of application, precise dosing, and aesthetic appeal enhance patient compliance.
- Simplified product development and manufacturing processes make TSS a promising advancement in transdermal drug delivery.
More Related Videos
04:22Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
Published on: March 30, 2017
7.2K
08:26Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
Published on: January 30, 2026
442
Related Concept Videos
01:18Transdermal Drug Delivery Systems
222
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
222
01:28Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
200
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
200
01:22Drug Delivery: Miscellaneous Routes
1.1K
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
1.1K
01:21Intrauterine Drug Delivery Systems
161
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
161
01:27Drug Delivery Systems: Different Types
386
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
386
01:26Oral Drug Delivery Systems: Continuous-Release Systems
288
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
288