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Related Experiment Video

Updated: Apr 23, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

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Hormonal contraception, thrombosis and age.

Øjvind Lidegaard1

  • 1University of Copenhagen, Department of Obstetrics and Gynecology, Faculty of Health Science, 4232, Rigshospitalet , Copenhagen 2100 , Denmark Oejvind.Lidegaard@regionh.dk.

Expert Opinion on Drug Safety
|September 18, 2014
PubMed
Summary

Combined hormonal contraceptives with certain progestins significantly increase thrombosis risk. Progestin-only options are safer, especially for women over 35 or with risk factors.

Keywords:
agehormonal contraceptionoral contraceptivesthrombosisvenous thrombosis

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Last Updated: Apr 23, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

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Area of Science:

  • Reproductive Health
  • Pharmacology
  • Thrombosis Risk Assessment

Background:

  • Hormonal contraception use is widespread among women of reproductive age.
  • Understanding the comparative risks of different contraceptive formulations is crucial for informed decision-making.

Purpose of the Study:

  • To review and compare the risk of thrombosis associated with various hormonal contraceptive types.
  • To provide guidance on contraceptive selection based on age and individual risk factors.

Main Methods:

  • Review of existing literature on hormonal contraception and thrombosis risk.
  • Categorization of combined hormonal contraceptives into high-risk and low-risk groups based on progestin type.
  • Analysis of risks for venous thromboembolism, thrombotic stroke, and myocardial infarction.

Main Results:

  • High-risk combined hormonal contraceptives (desogestrel, gestodene, drospirenone, cyproterone acetate) increase venous thromboembolism risk sixfold compared to non-users.
  • Low-risk combined hormonal contraceptives (norethisterone, levonorgestrel, norgestimate) carry a lower thrombosis risk.
  • Transdermal patches and vaginal rings are classified as high-risk products.
  • Progestin-only contraceptives generally do not increase thrombosis risk, with depot progestins showing a potential doubling of venous thrombosis risk.

Conclusions:

  • For women under 35 without contraindications, low-risk combined oral contraceptives with minimal estrogen are recommended.
  • Women over 35 or with thrombosis risk factors (obesity, diabetes, hypertension, smoking, etc.) should avoid high-risk products.
  • Progestin-only contraceptives are a preferred alternative for women with increased thrombosis risk.