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Study Design for Navigated Repetitive Transcranial Magnetic Stimulation for Speech Cortical Mapping
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Effects of navigated TMS on object and action naming
Julio C Hernandez-Pavon1, Niko Mäkelä1, Henri Lehtinen2
1Department of Biomedical Engineering and Computational Science, Aalto University School of Science Espoo, Finland ; BioMag Laboratory, HUS Medical Imaging Center, Helsinki University Central Hospital Helsinki, Finland.
Frontiers in Human Neuroscience
|September 18, 2014
Summary
Repetitive navigated transcranial magnetic stimulation (nTMS) more effectively disrupts object naming than action naming. This finding suggests object naming tasks are more sensitive for mapping speech areas in the brain using nTMS.
Area of Science:
- Neuroscience
- Cognitive Science
- Speech and Language Pathology
Background:
- Transcranial magnetic stimulation (TMS) is utilized to investigate speech disturbances and performance.
- Repetitive navigated TMS (nTMS) enables non-invasive mapping of cortical speech areas.
- Different naming tasks may yield distinct information crucial for presurgical evaluations.
Purpose of the Study:
- To assess the sensitivity of object and action naming tasks to nTMS.
- To compare the cortical distribution of nTMS-induced naming errors between object and action naming.
Main Methods:
- Eight healthy subjects performed object and action naming tasks during repetitive nTMS on semi-random left-hemispheric sites.
- Baseline naming performance was recorded before nTMS application.
- nTMS-induced naming errors were analyzed offline, categorized by type and location.
Main Results:
- nTMS induced no-response errors, phonological paraphasias, and semantic paraphasias.
- Seven of eight subjects exhibited more errors during object naming compared to action naming.
- Object naming demonstrated significantly higher sensitivity to nTMS disruptions, both within and between subjects.
Conclusions:
- Object naming is more susceptible to disruption by TMS than action naming.
- Utilizing different stimulus types in nTMS can help delineate specific aspects of speech functions.
- This research offers novel approaches for basic and clinical studies of cortical speech representations.
