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Updated: Apr 23, 2026

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
[Characteristics of aging skin]
Abstract:
The change in the population's age structure in most industrial countries, as in Germany, requires geriatric medicine to play an increasingly important role. Dermatology also has to meet the new challenges by expert discussion and ethical considerations. The physiological aging process is influenced by intrinsic and extrinsic factors and causes a variety of morphological and functional alterations in the skin. Those alterations are the cause for an increasing prevalence of many dermatoses. Infections, wound healing disorders, inflammatory diseases, tumors and associated paraneoplastic syndromes are of particular importance. The structural and functional characteristics of aging skin in combination with the reduced mobility and declining cognitive abilities in elder patients require specific recommendations for skin protection as well as qualified advice about topical and systemic use of medications.
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