Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Incomplete Dominance01:43

Incomplete Dominance

18.8K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
18.8K
The Ratio of X Chromosome to Autosomes02:45

The Ratio of X Chromosome to Autosomes

11.5K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
11.5K
Pedigree Analysis01:35

Pedigree Analysis

78.6K
Overview
78.6K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

1.4K
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.4K
Natural Selection and Mating Preferences01:06

Natural Selection and Mating Preferences

832
The principle of natural selection posits that organisms better adapted to their environment are more likely to survive and reproduce. This principle is closely intertwined with mating preferences, a key aspect of sexual selection, which evolutionary psychologists believe is driven by instincts to propagate one's genes. Such instincts significantly influence mating behaviors and preferences between genders.
Females, due to their biological roles in conception, pregnancy, and nursing,...
832
Genetic Variation01:25

Genetic Variation

1.6K
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biological Sex Is Binary and Rooted in Anisogamy.

Ecology letters·2026
Same author

Navigating the semantic labyrinth of "sex" in the study of reproductive trait evolution.

Integrative and comparative biology·2026
Same author

The evolution of suppressed recombination between sex chromosomes and the lengths of evolutionary strata.

Evolution; international journal of organic evolution·2025
Same author

Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology.

BMC biology·2025
Same author

The adaptive value of recombination in resolving intralocus sexual conflict by gene duplication.

Proceedings. Biological sciences·2025
Same author

Consequences of partially recessive deleterious genetic variation for the evolution of inversions suppressing recombination between sex chromosomes1.

Evolution; international journal of organic evolution·2024

Related Experiment Video

Updated: Apr 23, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

12.4K

Sex differences in disease genetics: evidence, evolution, and detection.

William P Gilks1, Jessica K Abbott2, Edward H Morrow1

  • 1Evolution, Behaviour, and Environment Group, School of Life Sciences, University of Sussex, Falmer BN1 9QG, UK.

Trends in Genetics : TIG
|September 21, 2014
PubMed
Summary

Sexual selection significantly impacts the genetic basis of complex traits and diseases. Evolutionary genetics research reveals sex-specific genetic variations contributing to disease risk, potentially maintained by sexual conflict.

Keywords:
GWASGxScomplex traitdiseaseintra-locus sexual conflictsexual selection

More Related Videos

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

22.2K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.2K

Related Experiment Videos

Last Updated: Apr 23, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

12.4K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

22.2K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.2K

Area of Science:

  • Evolutionary genetics
  • Human genetics
  • Disease genetics

Background:

  • Understanding complex disease genetics is challenging.
  • Evolutionary principles are crucial for disease architecture studies.
  • Sexual selection influences complex trait genetic architecture.

Purpose of the Study:

  • Summarize evidence for sex-dependent genetic variation in disease.
  • Discuss methods for discovering sex-specific genetic effects.
  • Explore evolutionary mechanisms maintaining these variations.

Main Methods:

  • Review of heritability studies.
  • Analysis of genome-wide association studies (GWASs).
  • Utilizing joint interaction analysis and new software.

Main Results:

  • Common genetic variation affects diseases and traits in a sex-dependent manner.
  • Joint analysis improves discovery of sex-specific effects.
  • Intra-locus sexual conflict may maintain disease risk alleles.

Conclusions:

  • Sex-dependent genetic effects are significant in disease.
  • Evolutionary forces, particularly sexual conflict, shape disease genetics.
  • Further research into sexual conflict's role in disease is warranted.