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The Cochlea01:13

The Cochlea

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The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
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Related Experiment Video

Updated: Apr 23, 2026

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
08:51

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

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Binaural interaction in the auditory brainstem response: a normative study.

Lindsey N Van Yper1, Katrien Vermeire2, Eddy F J De Vel3

  • 1Ghent University, Department of Otorhinolaryngology, Ghent, Belgium.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|September 22, 2014
PubMed
Summary

This study shows that 500 Hz tone-burst auditory brainstem response binaural interaction components (TB ABR-BICs) are reliable for assessing binaural hearing, especially in cochlear implant users with low-frequency residual hearing.

Keywords:
ABRAuditory brainstem responseBinaural difference waveBinaural interaction componentNormal

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Area of Science:

  • Neuroscience
  • Audiology
  • Auditory Neuroscience

Background:

  • Binaural interaction, crucial for sound localization and speech comprehension, can be assessed using auditory evoked potentials.
  • The auditory brainstem response binaural interaction component (ABR-BIC) provides evidence of binaural interaction at the brainstem level.
  • While click ABR-BICs are well-studied, data on 500 Hz tone-burst (TB) ABR-BICs are limited.

Purpose of the Study:

  • To characterize the features of both click and 500 Hz TB ABR-BICs.
  • To evaluate the reliability of click and 500 Hz TB ABR-BICs.
  • To explore the potential of 500 Hz TB ABR-BIC for specific patient populations.

Main Methods:

  • Auditory brainstem responses (ABRs) were recorded in 18 normal-hearing young adults using clicks and 500 Hz tone-bursts.
  • ABR-BICs were calculated by subtracting the binaural response from the sum of individual monaural responses.
  • Inter-rater reliability was assessed for both click and 500 Hz TB ABR-BICs.

Main Results:

  • Both click and 500 Hz TB ABR-BICs demonstrated good inter-rater reliability.
  • The most reliable peak for click ABR-BIC appeared at a mean latency of 6.06 ms.
  • Reliable 500 Hz TB ABR-BICs were observed with a mean latency of 9.47 ms, and exhibited larger amplitudes than click ABR-BICs.

Conclusions:

  • The most reliable click ABR-BIC peak is located on the downslope of wave V.
  • 500 Hz TB ABR-BIC is characterized by a broad positivity around wave V.
  • 500 Hz TB ABR-BIC is a promising technique for evaluating binaural interaction in populations like cochlear implant users with low-frequency residual hearing.