Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

28.6K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
28.6K
Epigenetic Regulation01:37

Epigenetic Regulation

3.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.3K
Epigenetic Regulation01:46

Epigenetic Regulation

23.9K
23.9K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.0K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.0K
Gene-Environment Interactions01:20

Gene-Environment Interactions

1.4K
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
1.4K
Histone Modification02:32

Histone Modification

14.4K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
14.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adolescent and Young Adult Perspectives on Receiving Pathogenic or Likely Pathogenic Results in a Prospective Genomic Screening Clinical Trial.

Public health genomics·2026
Same author

Participant Choice of Centralized or Remote Trial Engagement: Secondary Analysis of a Nonrandomized Clinical Trial.

JAMA network open·2026
Same author

Community Engagement as a Strategy for Bi-Directional Consensus Building Around Consciousness and Human Brain Organoids.

AJOB neuroscience·2026
Same author

Decisional Conflict Among Adolescents and Young Adults Before and After Facilitated Decision-Making About Learning Personal Genomic Information.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine·2026
Same author

Fibroids and health disparities: the COllaboration for EQuity in Uterine Leiomyomas specialized center.

American journal of obstetrics and gynecology·2026
Same author

Lessons Learned in Clinical Trial Recruitment: A Partnership Between a Genomic Research Study and the Discover Together Biobank.

Biopreservation and biobanking·2025
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
Same journal

The myth of asexual fungi.

Trends in genetics : TIG·2026
Same journal

Rethinking molecular evolution through protein language model embeddings.

Trends in genetics : TIG·2026
Same journal

Co-transcriptional splicing: Distinct phases, mutual benefits, and basis for nuclear architecture.

Trends in genetics : TIG·2026
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.1K

Serving epigenetics before its time.

Eric T Juengst1, Jennifer R Fishman2, Michelle L McGowan3

  • 1University of North Carolina, Chapel Hill, NC, USA.

Trends in Genetics : TIG
|September 23, 2014
PubMed
Summary
This summary is machine-generated.

Translating mouse epigenetic research into human health applications prematurely raises significant ethical concerns and burdens for prospective parents. Further research is needed before applying these findings to human disease prevention.

More Related Videos

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.0K
Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

23.5K

Related Experiment Videos

Last Updated: Apr 23, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.1K
An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.0K
Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

23.5K

Area of Science:

  • Epigenetics
  • Translational Science
  • Bioethics

Background:

  • Society values rapid application of basic biological discoveries to human health.
  • Epigenetic research in animal models is advancing quickly.
  • Translating findings across species presents challenges.

Purpose of the Study:

  • To examine the ethical and social implications of prematurely applying murine epigenetic findings to human disease prevention.
  • To assess the feasibility and potential burdens of such applications on prospective parents.

Main Methods:

  • Literature review of current epigenetic research in mice.
  • Analysis of ethical frameworks for scientific translation.
  • Discussion of social impacts on reproductive choices.

Main Results:

  • Current murine epigenetic findings are not directly or safely applicable to human disease prevention.
  • Premature translation imposes unrealistic expectations and ethical dilemmas on prospective parents.
  • Significant social and ethical questions arise regarding genetic and epigenetic interventions.

Conclusions:

  • A cautious approach is necessary when translating epigenetic research from animal models to human applications.
  • Ethical considerations and societal impact must be prioritized over rapid translation.
  • Further research is required to understand the long-term implications and safety of epigenetic modifications in humans.