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Updated: Apr 23, 2026
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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
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Pathogen inactivation technologies for cellular blood components: an update.
1Department for Blood Group Serology and Transfusion Medicine, Medical University Graz, Graz, Austria.
Summary
Blood safety has improved significantly, but emerging pathogens and bacterial contamination remain concerns. New pathogen inactivation technologies show promise for platelets, red blood cells, and whole blood, potentially revolutionizing blood product safety.
Area of Science:
- Transfusion Medicine
- Infectious Disease Prevention
- Blood Safety Technologies
Background:
- Transfusion-transmitted infectious diseases, including HIV, have decreased significantly over three decades.
- Emerging pathogens (e.g., arboviruses) and bacterial contamination of platelets remain key blood safety challenges.
- Established pathogen inactivation methods exist for plasma but are less developed for cellular blood components.
Purpose of the Study:
- To review available pathogen inactivation technologies for blood components.
- To assess their efficacy against viruses, bacteria, and protozoa.
- To evaluate their clinical impact through trials and hemovigilance data.
Main Methods:
- Pharmacological and toxicological assessment of technologies.
- Efficacy testing against a range of pathogens.
- Review of clinical trial outcomes and hemovigilance data.
Main Results:
- Pathogen inactivation technologies are effective against various pathogens.
- Some technologies are in routine use for plasma and platelets in Europe.
- Ongoing development targets red blood cells and whole blood.
Conclusions:
- Pathogen inactivation technologies are advancing for all blood components.
- These technologies offer a paradigm shift towards universally safer blood products.
- Universal applicability of these technologies is a future goal.
Keywords:
BacteriaBlood safetyChikungunya virusDengue virusHemovigilancePathogen inactivationPlatelet concentratesProtozoaRandomized clinical trialRed blood cellsWest Nile virusMore Related Videos
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