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Nanomedicine to overcome cancer multidrug resistance

Xi Yang, Cheng Yi, Na Luo

  • 1Department of Medical Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. chygong14@163.com.

Current Drug Metabolism
|September 27, 2014
PubMed

Insights

Nanotechnology offers promising strategies to overcome multidrug resistance (MDR) in cancer chemotherapy. Nanomedicine formulations show potential for improving treatment outcomes in patients with drug-resistant cancers.

Area of Science:

  • Oncology
  • Nanomedicine
  • Pharmacology

Background:

  • Cancer remains a significant global health challenge.
  • Multidrug resistance (MDR) severely limits the efficacy of conventional chemotherapy.
  • Overexpression of drug efflux pumps contributes to MDR by reducing intracellular drug accumulation.

Purpose of the Study:

  • To review pivotal nanotechnology-based strategies for combating cancer multidrug resistance (MDR).
  • To highlight the potential of nanomedicine in overcoming chemotherapy resistance.

Main Methods:

  • Review of preclinical studies on nanomedicine strategies against MDR.
  • Focus on enhanced permeability and retention (EPR) effect, stealth nanoparticles, endosomal escape, active drug delivery, stimuli-sensitive release, and targeted co-delivery.

Main Results:

  • Nanotechnology-based approaches demonstrate significant potential in overcoming MDR.
  • Strategies like EPR effect, prolonged circulation, and targeted delivery enhance therapeutic efficacy.

Conclusions:

  • Nanomedicine offers a promising avenue for improving the treatment of multidrug-resistant cancers.
  • Despite challenges, preclinical data strongly support the clinical application of nanomedicine for MDR cancer therapy.

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