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The Potential effect of G915C polymorphism in regulating TGF-β1 transport into Endoplasmic Reticulum for cytokine

Hani Susianti1, Atma Gunawan2, Jayarani Fatimah Putri3

  • 1Departement of Clinical Pathology, Faculty of Medicine, Brawijaya University, Malang, Indonesia.

Bioinformation
|September 27, 2014
PubMed
Summary

The G915C polymorphism in TGF-β1 may reduce cytokine production in Lupus Nephritis by altering signal peptide properties, hindering transport into the endoplasmic reticulum and lowering urinary TGF-β1 levels.

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