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Isolation and Th17 Differentiation of Na&#239;ve CD4 T Lymphocytes
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Tc17 Cells in Immunity and Systemic Autoimmunity.

Yan Liang1, Hai-Feng Pan, Dong-Qing Ye

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University , Hefei, Anhui , China.

International Reviews of Immunology
|September 27, 2014
PubMed
Summary

Interleukin-17 producing CD8(+) T cells (Tc17) are crucial in autoimmune diseases. Their plasticity and unique human characteristics offer potential therapeutic targets for autoimmune conditions.

Keywords:
CD8+T cellautoimmune diseasesimmunityinterleukin-17

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Area of Science:

  • Immunology
  • T cell biology
  • Autoimmunity

Background:

  • Tc17 cells, a subset of CD8(+) T cells, produce interleukin-17 (IL-17).
  • Their differentiation requires specific cytokines (IL-6, TGF-β1) and transcription factors (STAT3, RORγt, IRF4).
  • CD161 expression is significant for Tc17 cell function and identification in humans.

Purpose of the Study:

  • To provide an overview of murine and human Tc17 cell characteristics, including cytokines and chemokines.
  • To discuss the signaling pathways, molecular interactions, and transcriptional events governing Tc17 differentiation and function.
  • To explore the plasticity of Tc17 cells and their role in autoimmune diseases and memory formation.

Main Methods:

  • Review of existing literature on Tc17 cell differentiation, function, and plasticity.
  • Comparative analysis of Tc17 cells in murine models and human studies.
  • Focus on signaling pathways, transcriptional regulation, and cell surface markers like CD161.

Main Results:

  • Tc17 cells exhibit plasticity, converting to IFN-γ producing cytotoxic cells.
  • In vivo plasticity of Tc17 cells is implicated in the induction of autoimmune diseases.
  • Human Tc17 cells differ from murine counterparts, notably expressing CD161 and originating from CD161 precursors.

Conclusions:

  • Tc17 cells are key players in infection, cancer, and autoimmune inflammation.
  • The plasticity of Tc17 cells is a critical feature in autoimmune disease pathogenesis.
  • Tc17 cells represent promising therapeutic targets for autoimmune diseases, with potential for long-lived memory populations.