Related Experiment Video
Updated: Apr 23, 2026

Neutron Spin Echo Spectroscopy as a Unique Probe for Lipid Membrane Dynamics and Membrane-Protein Interactions
Published on: May 27, 2021
Structure of pravastatin and its complex with sodium dodecyl sulfate micelles studied by NMR spectroscopy
L F Galiullina1, I Z Rakhmatullin, E A Klochkova
1Institute of Physics, Kazan Federal University, 420008, Kazan, Russia.
Abstract:
The aim of this work was to study the mechanisms of interaction between pravastatin and cell membranes using model membranes (sodium dodecyl sulfate micelles) by nuclear magnetic resonance spectroscopy methods. On the basis of the nuclear magnetic resonance experiments, it was established that pravastatin can form intermolecular complexes with sodium dodecyl sulfate micelles by the interaction of its hydrophilic groups with the polar surface of the micelle. Conformational features of pravastatin molecule were also studied.
More Related Videos
Related Concept Videos
Spectroscopy of Carboxylic Acid Derivatives
NMR and Mass Spectroscopy of Carboxylic Acids
While α protons of carboxylic acids absorb at 2–2.5 ppm, β protons absorb further upfield.
Carboxylic acids are easily identified by dissolving them in deuterium oxide, which results in a rapid exchange of the acidic protons with deuterium. This leads to the...

