Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Adaptability of Cytoskeletal Filaments

Adaptability of Cytoskeletal Filaments

The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Surface-Enhanced Raman Spectroscopy: A Game Changer for Metabolomics Research.

Nano letters·2026

Same author

From hotspots to hotspaces: Cascaded photonic-plasmonic coupling for SERS-based deep profiling of whole small extracellular vesicles.

Science advances·2026

Same author

Conformationally Adaptive SERS Receptors: Reconfiguring Binding Environments via Dynamic <i>Gauche</i>-<i>Trans</i> Transitions for Broad-Spectrum Ion Sensing.

ACS applied materials & interfaces·2026

Same author

Interfacial Chemistry in SERS: Mechanisms, Controls, and Materials.

ACS applied materials & interfaces·2026

Same author

Dynamic Electrochemical Reorientation at SERS Hotspots Enables Composition, Length, and Sequence Reading of DNA Oligonucleotides.

Journal of the American Chemical Society·2026

Same author

Building a Foundation SERS Model for Lipids through Fatty Acid Pretraining for Annotation across Chemical Spaces.

ACS applied materials & interfaces·2026

Same journal

A Droplet-Microarray Platform for Multiplex Profiling of Breast Cancer Exosome Subtypes in Patients' Blood Plasma Samples.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

Material-Dependent Functionalization of CVD-Grown TMDC Monolayers Probed by Vibrational Nanospectroscopy.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

BandGap Modulated Charge Gating of Semiconductor Coatings Stabilizes Zinc Metal Anodes.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

For High Capacity: Upcycling of Spent Graphite Catalytic via Precisely Tailoring Water-Gas Reaction.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

Electronic Engineering of Donor-Acceptor Covalent Organic Frameworks via Fluorine Substitution for Efficient Solar Hydrogen Production.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same journal

Correction to: "A Gold Nanocage/Cluster Hybrid Structure for Whole-Body Multispectral Optoacoustic Tomography Imaging, EGFR Inhibitor Delivery, and Photothermal Therapy".

Small (Weinheim an der Bergstrasse, Germany)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 23, 2026

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

Shape-shifting 3D protein microstructures with programmable directionality via quantitative nanoscale stiffness

Mian Rong Lee¹, In Yee Phang, Yan Cui

¹Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371.

Small (Weinheim an Der Bergstrasse, Germany)

|September 30, 2014

Summary

This summary is machine-generated.

Researchers created 3D protein hydrogel microstructures that change shape in response to stimuli. This controlled shape-shifting, achieved by precisely altering cross-linking density, enables advanced smart microtechnology applications.

Keywords:

BSA chirality modulation cross-linking density pH responsive programmable directionality shape-shifting materials two-photon lithography

More Related Videos

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops

Published on: July 11, 2025

Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization

Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization

Published on: November 12, 2014

Related Experiment Videos

Last Updated: Apr 23, 2026

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops

Published on: July 11, 2025

Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization

Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization

Published on: November 12, 2014

Area of Science:

Materials Science
Biotechnology
Nanotechnology

Background:

Organismal shape-shifting enhances survival; analogous smart microtechnology is vital for human advancement.
Developing dynamic, responsive microstructures is a key goal in microtechnology.

Purpose of the Study:

To fabricate 10-30 μm shape-changing 3D protein hydrogel microstructures.
To achieve controlled, quantitative, directional, and angle-resolved bending in microstructures.
To demonstrate stimulus-induced chirality and pH-responsive microtraps.

Main Methods:

Utilized two-photon photolithography to create 3D bovine serum albumin (BSA) protein hydrogel microstructures.
Spatially controlled BSA cross-linking density at the nanometer scale to direct bending.
Employed atomic force microscopy to measure Young's moduli and correlate with laser writing parameters.

Main Results:

Demonstrated dynamic, quantitative, directional, and angle-resolved bending of microstructures.
Showcased that increasing laser writing z-axis distance (100-500 nm) decreases the structure's modulus.
Achieved precise control over swelling extent through nanoscale modulation of cross-linking density.

Conclusions:

Nanoscale control over cross-linking density via laser writing enables precise tuning of microstructure properties.
Developed a method for fabricating shape-shifting microstructures with stimulus-induced chirality.
Successfully created a free-standing 3D microtrap that opens and closes in response to pH changes.