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Updated: Apr 23, 2026

Procedure for Adaptive Laboratory Evolution of Microorganisms Using a Chemostat

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Published on: September 20, 2016

Combining experimental evolution with next-generation sequencing: a powerful tool to study adaptation from standing

C Schlötterer¹, R Kofler¹, E Versace²

¹Institut für Populationsgenetik, Vetmeduni Vienna, Vienna, Austria.

|October 2, 2014

Summary

Evolve and resequence (E&R) uses whole genome sequencing to find genetic changes during experimental evolution. This powerful method can identify genes and DNA variants linked to specific traits.

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Area of Science:

Evolutionary biology
Genomics
Molecular biology

Background:

Experimental evolution is a key method for studying adaptation.
Understanding the genetic basis of adaptation requires advanced genomic tools.

Purpose of the Study:

To review the Evolve and Resequence (E&R) method for studying genomic responses to selection.
To assess the power and limitations of E&R for identifying genetic variants.
To propose strategies for optimizing E&R in evolutionary research.

Main Methods:

Utilizes whole genome sequencing of pooled individuals (Pool-Seq).
Applies controlled and replicable experimental evolution settings.
Analyzes genomic data to detect selected variants.

Main Results:

E&R is a powerful approach capable of identifying causative genes and single-nucleotide polymorphisms.
Experimental design and trait complexity can lead to false positive candidate variants.
Strategies are suggested to enhance the accuracy of variant detection.

Conclusions:

Evolve and Resequence (E&R) is a valuable tool for linking genotype to phenotype.
Optimized experimental and analytical approaches are crucial for maximizing E&R's utility.
E&R can address a wide range of questions in evolutionary biology.