Related Experiment Video
Updated: Apr 23, 2026

Isolation of Culturable Yeasts and Molds from Soils to Investigate Fungal Population Structure
Published on: May 27, 2022
Methylthio-aspochalasins from a marine-derived fungus Aspergillus sp
Ying Liu1, Shizhe Zhao2, Wanjing Ding3
1Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China. liuy620@163.com.
Abstract:
Two novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of NMR and mass spectral data analysis. This is the first report about methylthio-substituted aspochalasin derivatives. Cytotoxicity against the prostate cancer PC3 cell line and HCT116 cell line was assayed using the MTT method. Apochalasin V showed moderate activity at IC50 values of 30.4 and 39.2 μM, respectively.
Related Concept Videos
Fungal Phylum Ascomycota
Antifungal Agents
Sulfur Assimilation
Bacterial Phylum Planctomycetes
Fungal Phylum Microsporidia
Preparation and Reactions of Sulfides

