Tenoxicam-kollicoat IR binary systems: physicochemical and biological evaluation

Area of Science:

• Pharmaceutical Technology
• Materials Science

Background:

• Tenoxicam (TNX) is a non-steroidal anti-inflammatory drug (NSAID) with limited solubility.
• Improving TNX dissolution rate is crucial for enhanced therapeutic efficacy.

Purpose of the Study:

• To develop and characterize tenoxicam binary systems using Kollicoat IR (KL) via kneading and spray-drying.
• To formulate and evaluate oral disintegrating tablets (ODTs) incorporating the optimized TNX-KL system.

Main Methods:

• Preparation of TNX-KL binary systems at various drug:polymer ratios using kneading and spray-drying.
• Characterization using dissolution rate studies, DSC, IR spectroscopy, and X-ray diffractometry.
• Formulation of ODTs with spray-dried TNX-KL and evaluation of disintegration, dissolution, and pharmacological activity.

Main Results:

• Both kneading and spray-drying enhanced TNX dissolution rate, with spray-drying showing superior results.
• Decreasing the drug:polymer ratio and achieving an amorphous state of TNX in the KL matrix further increased dissolution.
• ODTs with spray-dried TNX-KL (1:4 ratio) exhibited faster disintegration and dissolution than untreated TNX or commercial tablets.
• Pharmacological studies showed a significantly faster onset of anti-inflammatory and analgesic activity for ODTs containing spray-dried TNX-KL.

Conclusions:

• Spray-drying tenoxicam in a Kollicoat IR matrix is an effective method to enhance its dissolution rate and bioavailability.
• The developed ODTs offer a promising delivery system for improved therapeutic outcomes of tenoxicam.
• This approach significantly accelerates the onset of anti-inflammatory and analgesic effects.