Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.7K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.7K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.5K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.5K
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

19
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
19
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

1.1K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.1K
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

22
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
22
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

17
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
17

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to Fahey et al.

The American journal of gastroenterology·2023
Same author

Response to Catassi et al.

The American journal of gastroenterology·2023
Same author

Response to Rettally and Husby and Murray.

The American journal of gastroenterology·2023
Same author

Delayed Diagnosis in a Male With Congenital Chloride Losing Diarrhea.

JPGN reports·2023
Same author

American College of Gastroenterology Guidelines Update: Diagnosis and Management of Celiac Disease.

The American journal of gastroenterology·2023
Same author

Celiac Disease.

Pediatrics in review·2021
Same journal

Hemangiomas: Beyond the Skin.

Pediatrics in review·2026
Same journal

More Than Innocent: A Continuous Murmur in an Infant.

Pediatrics in review·2026
Same journal

Genetic Testing.

Pediatrics in review·2026
Same journal

Visual Diagnosis: Term Infant With a Hemorrhagic Dermatologic Lesion.

Pediatrics in review·2026
Same journal

Long-Term Complications of Sickle Cell Disease.

Pediatrics in review·2026
Same journal

Pediatric Multisystemic Illness With Cardiac Involvement: A Diagnostic Challenge.

Pediatrics in review·2026
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

23.9K

Celiac disease.

Tracy R Ediger1, Ivor D Hill2

  • 1Department of Clinical Pediatrics, The Ohio State University College of Medicine, and Department of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, OH.

Pediatrics in Review
|October 3, 2014
PubMed
Summary
This summary is machine-generated.

Celiac disease often presents with non-gastrointestinal symptoms in children and adolescents. Early diagnosis through serologic testing and biopsy, followed by a lifelong gluten-free diet, is crucial for managing celiac disease.

More Related Videos

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.6K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

6.7K

Related Experiment Videos

Last Updated: Apr 23, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

23.9K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.6K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

6.7K

Area of Science:

  • Pediatric Gastroenterology
  • Immunology

Background:

  • Celiac disease (CD) diagnosis in children often relies on recognizing both classic gastrointestinal symptoms and less common, atypical, non-gastrointestinal manifestations.
  • Guidelines advocate for celiac testing in symptomatic children, including those with atypical symptoms, and in individuals with associated conditions or a family history of CD.

Purpose of the Study:

  • To outline the diagnostic and management guidelines for celiac disease in pediatric populations.
  • To emphasize the importance of accurate serologic testing and timely referral for biopsy.

Main Methods:

  • Serologic testing using tissue transglutaminase immunoglobulin A (tTG IgA) and total serum IgA levels is the recommended primary diagnostic approach.
  • Upper endoscopy with biopsy is indicated for children with elevated celiac antibody titers or high clinical suspicion.

Main Results:

  • tTG IgA and total serum IgA testing is a cost-effective and accurate method for diagnosing celiac disease in children over two years old or those not IgA deficient.
  • Continued gluten ingestion is recommended until diagnostic procedures are completed.

Conclusions:

  • A confirmed celiac disease diagnosis necessitates a lifelong, strict gluten-free diet, avoiding wheat, barley, and rye.
  • Specialized healthcare professional guidance is essential for navigating the complexities of a gluten-free diet and identifying hidden gluten sources.