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Related Experiment Videos

Does nitroglycerin induce heparin resistance?

N E Lepor1, D K Amin, L Berberian

  • 1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048.

Clinical Cardiology
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

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Intravenous nitroglycerin does not cause heparin resistance. Studies showed no significant changes in activated partial thromboplastin time in vitro or in patients receiving nitroglycerin during heparin therapy.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Heparin is a critical anticoagulant in cardiovascular procedures.
  • Nitroglycerin is frequently used in patients undergoing percutaneous coronary interventions.

Purpose of the Study:

  • To investigate whether intravenous nitroglycerin induces heparin resistance.
  • To assess the impact of nitroglycerin on anticoagulation efficacy.

Main Methods:

  • In vitro assays using activated partial thromboplastin time (aPTT) and thrombin time (TT).
  • Prospective study of 10 patients undergoing coronary angioplasty, measuring aPTT before, during, and after nitroglycerin infusion while on continuous heparin.
  • Standard heparin dosing was maintained throughout the patient study.

Main Results:

Related Experiment Videos

  • Nitroglycerin did not alter aPTT or TT in vitro at concentrations up to 250 micrograms/ml.
  • The maximum reduction in aPTT in vitro was 7%.
  • In patients, aPTT values remained statistically similar (p=0.61) when on heparin alone, with nitroglycerin, and after nitroglycerin cessation.

Conclusions:

  • Intravenous nitroglycerin does not induce heparin resistance.
  • Short-term administration of nitroglycerin does not interfere with heparin's anticoagulant effect in patients undergoing coronary angioplasty.