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Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
Published on: February 27, 2018
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Magnesium metabolism in Huntington's chorea
Metabolism: Clinical and Experimental
|October 8, 2014
Summary
This study investigated magnesium metabolism in Huntington's chorea, finding no evidence of altered magnesium levels or metabolism in patients. Results do not support the hypothesis of magnesium dysregulation in this neurological condition.
Area of Science:
- Neurology
- Human Physiology
- Biochemistry
Background:
- Magnesium deficiency is linked to neurological symptoms like tremors and convulsions.
- Previous reports suggested altered magnesium metabolism in Huntington's chorea.
Purpose of the Study:
- To investigate magnesium metabolism in patients with Huntington's chorea.
- To evaluate the hypothesis of altered magnesium metabolism in this disease.
Main Methods:
- Studied 6 patients with Huntington's chorea.
- Conducted complete balance studies.
- Performed exchangeable magnesium, erythrocyte magnesium, and ultrafiltrable magnesium determinations.
- Assessed spinal fluid magnesium levels in 2 patients.
Main Results:
- Balance studies showed no abnormalities in magnesium.
- Exchangeable magnesium-28 values were within normal ranges.
- Erythrocyte, ultrafiltrable, and spinal fluid magnesium levels were also normal.
Conclusions:
- The findings do not support the hypothesis of altered magnesium metabolism in Huntington's chorea.
- Magnesium levels and metabolism appear normal in the studied patients.
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