[Two decades of progress in the diagnosis and treatment of differentiated thyroid cancer]

The clinical presentation of differentiated thyroid cancer (DTC) has changed considerably over the last two decades. This is mainly due to improvements in our capabilities to make an early diagnosis. As a result of these changes, a huge increase in the incidence of DTC has been seen worldwide, with the appearance of a much more indolent disease. During this period, significant progress has also been made in our understanding of the disease and today our approach to the DCT patient has changed completely. As we are entering an era of new technologies, we aim to review the major deveLopments considered as the milestones of these changes.