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Prostaglandin regulation of B-lymphocyte function

N D Staite1, G S Panayi2

  • 1Department of Medicine, Rheumatology Section, 14-169 Human Sciences, University of Minnesota, Minneapolis, MN55455, USA.

Immunology Today
|October 8, 2014
PubMed

The local production of prostaglandins (PGs) in tissues by monocytes, po lymorphonuclear leucocytes, endothelial cells and platelets, and their rapid degradation, gives PGs an ideal opportunity for the selective regulation of inflammatory and immune responses. Much is known about the PG regulation of monocyte and T-cell function(1-3) but our knowledge of PG-mediated regulation of B-lymphocytefunction is still very poor, with many apparent contradictions in the literature. Here Nigel Staite and Gabriel Panayi discuss the indirect and direct effects of PGs on B-lymphocyte function with particular emphasis on the regulation of human lymphocytes, acknowledging that most of what is known was learned from animal studies.

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