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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
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Is autoimmunity a side-effect of interleukin 2 production?
G Krämer1, K Schauenstein, G Wick
1Institute for General and Experimental Pathology, University of Innsbruck, Medical School, A- 6020 Innsbruck, Austria.
Immunology Today
|October 8, 2014
Summary
Interleukin 2 (IL-2) aids lymphocyte activation but may initiate and worsen autoimmune diseases. Researchers caution against its clinical use due to these risks.
Area of Science:
- Immunology
- Autoimmune Diseases
- Therapeutic Agents
Background:
- Interleukin 2 (IL-2) is known to play a role in lymphocyte activation.
- IL-2 has been investigated as a therapeutic agent for various immune dysfunctions in both animals and humans.
Purpose of the Study:
- To discuss the potential role of IL-2 production in initiating and perpetuating autoimmune diseases.
- To express caution regarding the clinical application of IL-2.
Main Methods:
- Review of existing research on IL-2's function in immune responses.
- Analysis of the potential link between IL-2 production and the development of autoimmune conditions.
Main Results:
- IL-2's involvement in lymphocyte activation is established.
- Concerns are raised about IL-2's potential to trigger and sustain autoimmune diseases.
Conclusions:
- The clinical use of IL-2 warrants caution due to its possible role in autoimmune pathogenesis.
- Further investigation is needed to fully understand the risks and benefits of IL-2 therapy in immune-related conditions.
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