Related Experiment Video
Updated: Apr 22, 2026
16:01
Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
Published on: January 26, 2015
11.8K
Synthesis and secretion of eosinophil granule substances
1Department of Immunology, St George's Hospital Medical School, Cranmer Terrace, Tooting, London SW I7 ORE, UK.
Immunology Today
|October 8, 2014
Summary
Recent research advances have clarified eosinophil production, molecular functions, and their effects on parasites and tissues. This review summarizes key findings on these crucial immune cells.
Area of Science:
- Immunology
- Cell Biology
Background:
- Eosinophils are key immune cells with diverse roles.
- Recent years have seen significant advancements in understanding eosinophils.
Purpose of the Study:
- To review recent research on eosinophils.
- To highlight key findings in eosinophil biology.
Main Methods:
- Review of recent scientific literature.
- Synthesis of current knowledge on eosinophils.
Main Results:
- Eosinophil production regulation is now better understood.
- Eosinophils synthesize and release various biologically important molecules.
- The effects of eosinophil products on parasites, cells, and tissues have been elucidated.
Conclusions:
- Significant progress has been made in eosinophil research.
- This knowledge is crucial for understanding immune responses and host-parasite interactions.
Related Concept Videos
01:33Overview of Secretory Vesicles
8.7K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
8.7K
01:30Classification of Leukocytes
8.7K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
8.7K
01:15Differentiation of Common Myeloid Progenitor Cells
3.1K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.1K
01:26Asthma-II: Pathophysiology and Classification
4.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.6K
01:28Asthma I: Introduction
40
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
40
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
1.8K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
1.8K