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Updated: Apr 22, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Clonal analysis of the cytolytic T-cell response to human tumors
A Anichini1, G Fossati, G Parmiani
1Division of Experimental Oncology D, Istituto Nazionale Tumori, Via G. Venezian, 1, 20133 Milan, Italy.
Abstract:
A variety of cloning techniques are being applied to the analysis of phenotype, specificity and mechanism of action of cytolytic T cells on autologous tumor cells. Technical factors are influencing the results and interpretation of these studies but, as Andrea Anichini and colleagues show here, this analysis has revealed that the cytotoxic response can be multiclonal, mediated by multiple mechanisms and directed to different groups of determinants expressed on the same tumor cells.
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