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Updated: Apr 22, 2026

Reverse Genetic Approach to Identify Regulators of Pigmentation using Zebrafish
Published on: March 1, 2022
[New classification and genetic background of inherited ichthyoses]
Rikke Elkjær Andersen1, Jens Michael Hertz, Anette Bygum
1Hudafdeling I og Allergicentret, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C.
Abstract:
A new classification of inherited ichthyoses is presented based on clinical features, genetic background and pathophysiology. Ichthyoses are disorders of cornification and may be part of syndromes. Ichthyosis vulgaris, X-linked ichthyosis, autosomal recessive congenital ichthyosis and syndrome-related variants are described. Severe forms can be potentially life-threatening. Dry scaly skin can be disabling and time-consuming, as the patient needs topical therapy and sometimes also systemic retinoids. Treatment today is symptomatic, but hopefully new knowledge will lead to targeted therapies.
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