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Updated: Apr 22, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
19.1K
[Sumatriptan plus naproxen for acute migraine attacks in adults]
Henrik W Schytz, Lars Bendtsen1
1Dansk Hovedpinecenter, Glostrup Hospital, Nordre Ringvej 57, 2600 Glostrup.
Ugeskrift for Laeger
|October 9, 2014
Summary
Combining sumatriptan and naproxen offers improved acute migraine treatment effectiveness compared to sumatriptan alone. However, this combination therapy is best reserved for patients unresponsive to triptans due to a high number needed to treat.
Area of Science:
- Neurology
- Pharmacology
Context:
- Acute migraine treatment requires improved therapeutic options.
- Non-steroidal anti-inflammatory drugs (NSAIDs) and triptans possess distinct anti-nociceptive mechanisms.
- Combination therapy may enhance acute migraine attack management.
Purpose:
- To evaluate the efficacy of a combined sumatriptan and naproxen treatment for acute migraine attacks.
- To compare the effectiveness of the combination therapy against monotherapy with sumatriptan.
Summary:
- A meta-analysis demonstrated that the combination of sumatriptan and naproxen was more effective than sumatriptan alone for acute migraine treatment.
- The study identified a high number needed to treat (NNT) for the combination therapy.
- The findings suggest that combined sumatriptan/naproxen should be considered for patients who do not respond adequately to triptans.
Impact:
- Provides evidence for a potentially more effective acute migraine treatment strategy.
- Highlights the need to consider patient-specific responses when selecting migraine therapies.
- Informs clinical decision-making regarding the use of combination pharmacotherapy for migraine.
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