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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Hippo pathway regulation of gastrointestinal tissues

Fa-Xing Yu1, Zhipeng Meng, Steven W Plouffe

  • 1Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093;

Annual Review of Physiology
|October 9, 2014
PubMed

Insights

The Hippo pathway regulates organ size and homeostasis. Its dysregulation, particularly involving Yap, contributes to gastrointestinal cancers and impacts tissue repair.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gastroenterology

Background:

  • The Hippo pathway is a critical regulator of organ size and tissue homeostasis.
  • Dysregulation of the Hippo pathway, especially its effector Yap, is implicated in human cancers.
  • The pathway's role in gastrointestinal tissues is increasingly recognized.

Purpose of the Study:

  • To provide an overview of the Hippo pathway.
  • To discuss the physiological and pathological roles of the Hippo pathway in gastrointestinal tissues.
  • To highlight the involvement of Yap in gastrointestinal organ development and disease.

Main Methods:

  • Review of existing literature on the Hippo pathway and Yap.
  • Analysis of mouse model studies investigating Hippo pathway components and Yap.
  • Examination of data related to gastrointestinal tissue homeostasis and cancer.

Main Results:

  • Inducible Yap expression in mice causes organ overgrowth.
  • Hippo pathway component knockout or Yap overexpression leads to liver enlargement and hepatocellular carcinoma.
  • In the intestine, Hippo pathway component deletion causes progenitor cell expansion and adenoma development, while Yap is crucial for repair.

Conclusions:

  • The Hippo pathway, through Yap, plays significant roles in gastrointestinal tissue homeostasis, organ size control, and cancer development.
  • Understanding the Hippo pathway's function is vital for addressing gastrointestinal pathologies, including cancer and tissue injury response.
Keywords:
Mst1Mst2Yapcancerintestineliverregeneration

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