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Updated: Apr 22, 2026

Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain
Published on: May 12, 2018
[Potential neurotoxicity of general anaesthetics to the developing brain]
Nicola G Clausen1, Søren Venø, Mads Astvad
1Anæstesiologisk-intensiv Afdeling V, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C. nicola@nicola.dk.
Abstract:
Animal studies (including non-human primates) have shown that most general anaesthetics cause enhanced neuroapoptosis with subsequent long-term neurocognitive deficits later in life. Some human cohort studies have indicated an association between anaesthesia/surgery and adverse neurocognitive outcome whereas other studies have not. Overall, the data do not justify any change in paediatric anaesthetic clinical practice. Naturally, the risks and benefits of a procedure should always be carefully considered before exposing a child to general anaesthesia.
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