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Published on: February 7, 2019
The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a
Sarah K Casper1, Scott J Schoeller, Danielle M Zgoba
1Department of Biological Sciences, University of Wisconsin-Whitewater, Whitewater, Wisconsin, 53190; Department of Health Sciences, Blackhawk Technical College, Janesville, Wisconsin, 53545.
Abstract:
Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that B. malayi DAF-16a is a member of the FOXO family of forkhead proteins.
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