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Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed...
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Radionuclides in drug development.

Philipp Uhl1, Gert Fricker2, Uwe Haberkorn3

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Radionuclides are crucial in personalized medicine and drug development, enabling molecular imaging and targeted therapies. This review covers their applications from target identification to advanced imaging techniques.

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Area of Science:

  • Medical sciences
  • Radiochemistry
  • Pharmacology

Background:

  • Molecular imaging is vital for personalized therapies.
  • Radionuclides play a critical role in drug development.
  • Current methods span various stages of therapeutic research.

Purpose of the Study:

  • To provide a comprehensive overview of radionuclide applications in medical sciences.
  • To highlight the potential of radionuclides in drug development.
  • To discuss radiolabeling, instrumentation, and limitations.

Main Methods:

  • Review of existing literature on radionuclide use.
  • Analysis of applications from autoradiography to molecular imaging.
  • Examination of drug development processes involving radionuclides.

Main Results:

  • Radionuclides are essential for target identification, pharmacokinetics, and endoradiotherapy.
  • Various radiolabeling techniques and their limitations are discussed.
  • Instrumentation technologies for radionuclide applications are presented.

Conclusions:

  • Radionuclides offer significant potential across diverse drug classes and therapeutic strategies.
  • Understanding radiolabeling and instrumentation is key to successful implementation.
  • Molecular imaging with radionuclides advances personalized medicine.